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There is a tendency to sickness rate increase in the world at the moment. The optimal way to solve this problem is creation and study of new original medicines with a high selectivity of action along with low toxicity and minimal side effects. An expedient way to accomplish this task is to design new medicines by means of modification of already tested and approved bioactive substances and their targeted functionalization by pharmacophore groups. One of the most promising objects of this research type is heterocyclic system of imidazole known as a key structural fragment of many natural physiologically active substances, pharmacologically active substances and effective synthetic medicines (metronidazole, clotrimazole, losartan, etc.) which are characterized by a wide range of biological properties. The mentioned facts are evidence of expedience of search for new bioactive substances among imidazole derivatives functionalized with thioacetic acid residue in order to create new medicines.